.406 Ventures

Venture Capital Active Boston, United States Est. 2005
Visit website ↗ LinkedIn
Last updated 2026-06-18
Portfolio
3
in our dataset
Rounds participated
9
Rounds led
0
Rounds' value
$156.0M
total disclosed, rounds participated
Stages
A Round, Seed, Pre-Seed

About

406 Ventures is a venture capital firm based in Boston, Massachusetts, focused on early-stage investments in technology-driven companies. The firm primarily targets sectors such as enterprise software, healthcare IT, and cybersecurity. With a strong emphasis on partnering with innovative startups, 406 Ventures provides capital, strategic guidance, and industry expertise to help companies scale and succeed. The firm is known for its hands-on approach, working closely with founders to navigate challenges and capitalize on growth opportunities in rapidly evolving markets

Portfolio · 3

Retrain.ai
Talent-management Platform for Enterprises and Government Agencies
3 rounds $25.0M committed Latest: 2022-12
Vaultive
Cybersecurity Solutions for Cloud Data and Applications
2 rounds $18.0M committed Latest: 2015-01
Kaltura
Video Cloud Platform
4 rounds $113.0M committed Latest: 2014-02

Investment activity

2 portfolio exits on record.

Portfolio by sector

Business Software2
Cyber Security1

Funds · 1

  • 5 — $265M Feb 2024

Q&A

What is .406 Ventures' primary investment focus?
.406 Ventures is a venture capital firm based in Boston, Massachusetts, focused on early-stage investments in technology-driven companies, primarily targeting sectors such as enterprise software, healthcare IT, and cybersecurity.
When was .406 Ventures founded?
.406 Ventures was founded in 2005.
Has .406 Ventures recently raised a new fund?
Yes, .406 Ventures secured $265 million for Fund 5 in February 2024.
Which of .406 Ventures' portfolio companies has had a notable exit?
.406 Ventures saw an exit with Kaltura, which went public on NASDAQ in July 2021 with a valuation of $1.3 billion. Another notable exit was Vaultive, acquired by CyberArk in March 2018.
Who are the managing partners at .406 Ventures?
The managing partners at .406 Ventures are Maria Cirino and Liam Donohue.
What are some of .406 Ventures' portfolio companies?
Notable portfolio companies of .406 Ventures include Kaltura, a video cloud platform, and Retrain.ai, a talent-management platform.
What stages of investment does .406 Ventures typically focus on?
.406 Ventures primarily focuses on Seed, Pre-Seed, and A Round investments.
What is the geographic focus of .406 Ventures?
.406 Ventures is based in Boston, Massachusetts, United States.
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