Sensotrade is a financial analysis company using multidisciplinary methods, such as algorithms based on research in medicinal chemistry with proven results in the field, some of which are used in the pharmaceutical industry. Some algorithms, that are being used to find medicines in the contemporary market, are based on stochastic/chaotic methods. On the one hand, they are being used to successfully find medicinal solutions for deterministic problems; and on the other hand, Sensotrade found that these algorithms work better for more chaotic problems, in our case the world of trading. Sensotrade has taken large data optimization algorithms, currently used in the fields of Computational Chemistry, Bioinformatics and Chemoinformatics and optimized them using its proprietary tools and datasets to create computational engines for ranking stocks and bonds. These ranking engines can then be utilized for investment portfolio optimization algorithms. The engine ranking of 9 market weighted indices (TA100, S&P500, BVSP, N225, DAX, FCHI,FTSE, HSI, BSESN) during the years 2006-2010, compared to the annual ranked index returns is demonstrated in.