Proteologics

Discovering Cancer Inhibition Therapy

Health Tech & Life Sciences
Acquired by Zmiha Investment House Ltd.
Acquired , Israel Founded 1999
Last updated 2026-08-22
Total raised
$82.5M
Stage
Acquired
Founded
1999
Headcount
6
HQ
, Israel
Sector
Health Tech & Life Sciences

About

Proteologics Ltd is a biopharmaceutical company exploiting the ubiquitin system for the discovery and development of novel therapeuticsforcancer treatment. The reserach was performed byidentifying correlations between ubiquitin pathway components and pathological conditions. The ubiquitin system was discovered by two Israeli Nobel Prize Laureates, Avram Hershko and Aaron Ciechanover. Proteologics hasexploited the ubiquitin system for the novel therapeutics,focusing primarily on discovering inhibitors for specific E3 ubiquitin ligases. In 2012, XTLBiopharmaceuticals Ltd. (Pink Sheets:XTLBY; TASE:XTL) acquired 31% stake in Proteologics. Until then,Teva Pharmaceutical Industries Ltd. was the controlling shareholder in Proteologics. In Sept. 2013, Zmiha Investment House Ltd. (TASE: TZMI) has acquired control of Proteologics Ltd. from XTL Biopharmaceuticals Ltd. for NIS 12.1 million, including the control premium. Zmiha, a licensee in the Yam 3 offshore oil and gas exploration license, bought 6,738,828 Proteologics shares, 44.95% of the company. At that point, Proteologicsdecided to freeze its research activity. However, itsStocks have been tradedontheTASE. In addition, Proteologicshas several initial joint-development agreements with big pharma companies.

Funding history · 4 rounds · $82.5M total

4 events/rounds · $82.5M Total Funding: $73.0M in Private Equity, $9.4M in Public Equity
Mar 2010
Follow-on PO $9.4M globes.co.il ↗
★ Leumi Partners Ltd.★ Clal Finance Underwriting Ltd.★ Meitav Issuing And Finance Ltd.★ Barak Capital Underwriting Ltd.★ Menora Mivtachim Underwriters & Management Ltd.GlaxoSmithKline plc
Jan 2010
C Round $30.0M globes.co.il ↗
★ Lewis Pell★ Morris Kahn★ Concord Ventures★ Giza Venture Capital★ Prof. Shlomo Ben-Haim★ Challenge Fund - Etgar★ Aurum Ventures MKI Ltd.★ Teva Pharmaceutical Industries Ltd.
May 2005
B Round $29.0M globes.co.il ↗
★ Concord Ventures★ Teva Pharmaceutical Industries Ltd.★ Reslo Life Sciences Ltd.★ Alex Brown Deutsche Bank (US)★ Giza Fund (GE Capital; Israel)TevaLewis PellShlomo Ben HaimReslo Life SciencesGiza Venture CapitalChallenge Fund - EtgarAlex Brown Deutsche BankABS Ventures (Deutsche Bank - Alex Brown)

Headcount over time

6 employees (2026-09) · 1 point
6 6 2026-09

Offices

, Israel · HQ / main office

Q&A

What is Proteologics' primary focus in biopharmaceutical research?
Proteologics is a biopharmaceutical company that exploits the ubiquitin system for the discovery and development of novel therapeutics, primarily focusing on discovering inhibitors for specific E3 ubiquitin ligases for cancer treatment.
When was Proteologics founded?
Proteologics was founded in May 1999.
What was the initial significant acquisition of a stake in Proteologics?
In 2012, XTL Biopharmaceuticals Ltd. acquired a 31% stake in Proteologics. Prior to this, Teva Pharmaceutical Industries Ltd. was the controlling shareholder.
Who acquired control of Proteologics in September 2013 and for what amount?
In September 2013, Zmiha Investment House Ltd. acquired control of Proteologics Ltd. from XTL Biopharmaceuticals Ltd. for NIS 12.1 million, including the control premium.
What was the immediate consequence of Zmiha Investment House Ltd.'s acquisition of Proteologics?
Following the acquisition by Zmiha Investment House Ltd. in September 2013, Proteologics decided to freeze its research activity.
How many employees does Proteologics have?
Proteologics has 1-10 employees.
What is the total amount of funding Proteologics has raised?
Proteologics has raised a total of $25,000,000 USD.
Does Proteologics hold any patents?
Yes, Proteologics holds 1 patent.

Team · 7

Gleb Zilberstein
Founder · Co-Founder
Uriel (Uri) Halavee
Founder · Co-Founder
Oded Lieberman
President and CEO
Josh Levine
CEO
Motti Hakim
Project Leader
Avram Hershko
Scientific Advisory Board Member
Aaron Ciechanover
Scientific Advisory Board Member

Sectors & technology

Primary sector
Health Tech & Life Sciences
Technologies
Target customers

Highlights

1 Patents

Tags

proteinspersonalized-medicinecell-therapytargeted-cancer-therapy
Full data — links, identifiers, deals & radar signals (jobs, patents, research, more)

External links

LinkedInlinkedin.com/company/129024

Identifiers & details

Legal nameProteologics Ltd.
Founded1999-5
Employees (exact)6
Status reasonAcquired (Inactive) by Zmiha Investment House Ltd. on Sep 2013 - closed due to acquisition

Acquisitions & public offerings

Acquired by Zmiha Investment House Ltd. 2013-09 $3.2M

Radar intelligence

Patents

EPO40

Publications (Crossref)

Works2

Israeli Companies Registrar (רשם החברות / ICA)

Registrar # (ח.פ.)512781386
Statusפעילה
Corp typeישראלית חברה ציבורית
Incorporated1999-05-19
Purposeלעסוק בסוגי עיסוק שפורטו בתקנון
Liabilityמוגבלת
In violation (unfiled)no
Last annual report2010
Active charges / liens0
Registry events0
Registered addressדרך בגין 55 תל אביב - יפו