Mental-Heal by Abital is developing a novel oral antipsychotic drug, PGW-5, for the treatment of schizophrenia and bipolar disorder. PGW-5 is a neuroleptic, multi-target agent that is potentially effective for the treatment of schizophrenia symptoms and other cognitive deficits and mood disorders. The possible mechanisms underlying the differential effects of the drugs may involve the brain glutamate NMDA (N-Methyl-D-Aspartate receptor) system as well as neurotrophic factors and food intake regulating peptides. Early scientific work in animal models has shown that PGW-5 has anxiolytic and antidepressant activity and improves impaired social performance in PCP-treated mice.
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