Last updated 2026-07-26
- Raised $900k Pre-Seed round led by Peregrine Ventures, Jan 2023
- Raised Seed round led by Peregrine Ventures, Sep 2025
Total raised
$900K
Last: Undisclosed Round 2025-10
Stage
Seed
Founded
2019
Headcount
1
HQ
Tel Aviv-Yafo, Israel
Sector
Health Tech & Life Sciences
About
Bio-ReFine is an Israeli medical device company in the field of interventional structural cardiology. It has developed a groundbreaking technology, the Coriofix™ system, which enables physicians to perform implant-less annuloplasty repair in a simple and safe endovascular procedure for mitral and tricuspid heart valves. This technology aims to treat patients suffering from mitral or tricuspid valve regurgitation who are currently ineligible for treatment due to the high risks associated with open-heart surgery.
Funding history · 2 rounds · $900K total
2025-09
Seed
Undisclosed
★ Peregrine Ventures
2023-01
Pre-Seed
$900K
★ Peregrine Ventures
Headcount over time
From 6 (2022-12) to 2 (2025-12) · -4 (-67%) · 3 points · source: Finder history + radar grounding
Q&A
- What is Bio Refine's primary focus?
- Bio Refine is an Israeli medical device company developing an implant-less annuloplasty repair system for mitral and tricuspid heart valves.
- When was Bio Refine founded?
- Bio Refine was founded in July 2019.
- How many employees does Bio Refine currently have?
- Bio Refine has 1-10 employees.
- What is the total amount of funding Bio Refine has raised to date?
- Bio Refine has raised a total of $2,530,000 USD.
- Which investors participated in Bio Refine's Seed round in February 2023?
- Peregrine Ventures participated in Bio Refine's Seed round in February 2023.
- Which investors participated in Bio Refine's Seed round in October 2025?
- Incentive Incubator and Peregrine Ventures participated in Bio Refine's Seed round in October 2025.
- What is the name of Bio Refine's core technology?
- Bio Refine's core technology is the Coriofix™ system, which enables implant-less annuloplasty repair for heart valves.
- Who is the Co-Founder and CEO of Bio Refine?
- Boaz Shenhav is the Co-Founder and CEO of Bio Refine.
Team · 1
Boaz Shenhav
Founder · Co-Founder & CEO
Sectors & technology
Primary sector
Health Tech & Life Sciences
Sub-sectors
Health Tech & Life SciencesMedical DevicesMedical Treatment & Therapeutics
Target customers
Healthcare & Life SciencesHealthcareProviders
Business model
B2B
Highlights
1 Patents
Tags
minimally-invasivevalvescardiologysurgery-toolsmedical-devices
Full data — links, identifiers, deals & radar signals (jobs, patents, research, more)
External links
| Website | bio-refine.com/ |
|---|---|
| linkedin.com/company/101043680 |
Identifiers & details
| Legal name | BIO REFINE LTD |
|---|---|
| Founded | 2019-7 |
| Employees (exact) | 1 |
Radar intelligence
Patents
| EPO | 6 |
|---|
Israeli Companies Registrar (רשם החברות / ICA)
| Registrar # (ח.פ.) | 516051497 |
|---|---|
| Status | פעילה |
| Corp type | ישראלית חברה פרטית |
| Incorporated | 2019-07-07 |
| Purpose | לעסוק בכל עיסוק חוקי |
| Liability | מוגבלת |
| In violation (unfiled) | no |
| Last annual report | 2024 |
| Active charges / liens | 1 |
| Registry events | 5 — shares_capital (1), other (1), charge (1), people (2) |
| Registered address | נתניהו יהונתן 6 אור יהודה |
Recent registry events
| Date | Event |
|---|---|
| 2025-12-30 | שינוי בהרכב הון - מניות-פיצול מניה |
| 2025-12-30 | שינוי בתקנון |
| 2026-05-28 | רישום שעבוד |
| 2025-12-25 | עדכון דירקטורים-הוספת דירקטור |
| 2026-02-23 | עדכון בעלי תפקידים |