Rebiotics Rx · raw details

Rebiotics Rx is focused on repurposing FDA-approved antibiotics to fight antibiotic-resistant bacteria. The flagship product of Rebiotics Rx is a PEGylated Nanoliposomal-mupirocin formulation. Mupirocin has a unique mode of action, not shared by any other available antibiotic. It is active against pathogens defined as urgent and serious threats to public health, such as Neisseria gonorrhea, methicillin-resistant Staphylococcus aureus, and Streptococcus pneumonia. However, its short half-life in circulation prevents its parenteral use and limits it to topical uses. Reformulation of mupirocin by the nanoliposomes substantially increases the systemic exposure to mupirocin and prolongs its half-life, thereby enabling the parenteral activity of mupirocin and practically resulting in a novel antibiotic with demonstrated efficacy in relevant animal models.