Protalix BioTherapeutics

A biopharmaceutical company developing plant cell-expressed enzyme replacement therapies for rare lysosomal storage disorders.

Health Tech & Life Sciences
Public on AMEX on Dec, 2006
Public on TASE on Nov, 2010
Public on NYSE on Mar, 2011
Public Karmiel, Israel Founded 1993
Last updated 2026-09-06
Total raised
$173.5M
Last: Public Offering 2021-02
Stage
Public
Founded
1993
Headcount
226
HQ
Karmiel, Israel
Sector
Health Tech & Life Sciences

About

Protalix is a biopharmaceutical company focused on the development, production, and commercialization of innovative medicines for patients living with rare diseases. The company is advancing promising candidates leveraging its expertise in protein therapeutics through its proprietary, commercial-scale ProCellEx plant cell-based protein expression system, as well as its chemical and genetic modification capabilities, including PEGylation. With two approved drugs already making an impact, Protalix is committed to expanding its pipeline to address the unmet needs of patients facing some of the most challenging rare diseases.

Funding history · 8 rounds · $173.5M total

13 events/rounds · $173.5M Total Funding: $5.3M in Private Equity, $255.6M in Public Equity
Aug 2025
Follow-on PO $15.7M EDGAR filing SEC-EDGAR filing SEC-EDGAR
Mar 2025
Follow-on PO $20.0M EDGAR filing SEC-EDGAR filing SEC-EDGAR
May 2022
Follow-on PO $20.0M EDGAR filing SEC-EDGAR filing SEC-EDGAR
Jul 2021
Follow-on PO $20.0M EDGAR filing SEC-EDGAR filing SEC-EDGAR
Jul 2021
Follow-on PO $13.8M EDGAR filing SEC-EDGAR filing SEC-EDGAR
Oct 2020
Follow-on PO $35.0M EDGAR filing SEC-EDGAR filing SEC-EDGAR
Mar 2020
PIPE $43.7M EDGAR filing SEC-EDGAR filing SEC-EDGAR
Jul 2005
C Round $5.3M wikipedia.org
★ Phillip Frost

Headcount over time

226 employees (2026-09) · 1 point
226 226 2026-09

Offices

Karmiel, Israel · HQ / main office

Q&A

What is Protalix BioTherapeutics' primary focus?
Protalix BioTherapeutics is a biopharmaceutical company that develops plant cell-expressed enzyme replacement therapies for rare lysosomal storage disorders.
When did Protalix BioTherapeutics go public on the NYSE?
Protalix BioTherapeutics went public on the NYSE in March 2011.
What is the employee count for Protalix BioTherapeutics?
Protalix BioTherapeutics has 226 employees, falling within the 201-500 employee bucket.
What was the amount raised in Protalix BioTherapeutics' Public Offering in February 2023?
In February 2023, Protalix BioTherapeutics raised $20,000,000 in a Public Offering.
What was the amount raised in Protalix BioTherapeutics' most recent Public Offering in March 2025?
In March 2025, Protalix BioTherapeutics raised $20,000,000 in a Public Offering.
What are the two FDA-approved products developed by Protalix BioTherapeutics?
Protalix BioTherapeutics has two FDA-approved products: Elelyso (taliglucerase alfa) for Gaucher disease and Elfabrio (pegunigalsidase alfa) for Fabry disease.
Which companies does Protalix BioTherapeutics collaborate with?
Protalix BioTherapeutics collaborates with Pfizer Inc. and Chiesi Global Rare Diseases.
When did Protalix BioTherapeutics announce the appointment of Gilad Mamlok as its new Senior Vice President and Chief Financial Officer?
Protalix BioTherapeutics announced the appointment of Gilad Mamlok as its new Senior Vice President and Chief Financial Officer on July 21, 2025.
When did Protalix BioTherapeutics and Secarna Pharmaceuticals enter into a collaboration and option agreement?
Protalix BioTherapeutics and Secarna Pharmaceuticals entered into a collaboration and option agreement on December 17, 2025.
When did Chiesi Global Rare Diseases and Protalix BioTherapeutics receive a positive CHMP opinion for an additional dosing regimen of Elfabrio in the EU?
Chiesi Global Rare Diseases and Protalix BioTherapeutics received a positive CHMP opinion for an additional dosing regimen of every four weeks for Elfabrio (pegunigalsidase alfa) in the EU on January 30, 2026.

Team · 14

Yoseph Shaaltiel
Founder · Board Member & Vice President, Research and Development
Dror Bashan
President & Chief Executive Officer, Director
Gilad Mamlok
Senior Vice President & Chief Financial Officer
Yaron Naos
Senior Vice President, Operations
Ori Kalid
Vice President, Research and Development
Shoshi Tessler
Vice President, Clinical Development & Regulatory Affairs
Tanya Gershanik
Vice President, Quality Affairs
Yael Fellous
Vice President, Human Resources
Eliot Forster
Chairman of the Board of Directors
Amos Bar Shalev
Director
Shmuel “Muli” Ben Zvi
Director
Pol F. Boudes
Director
Christian Elze
Director
Gwen Melincoff
Director

Sectors & technology

Primary sector
Health Tech & Life Sciences
Technologies
Target customers

Highlights

1 Patents

Tags

antibodiesoral-drugspharmaceuticalsproteinsgenetic-disordersplant-proteininflammatory-diseasespharma-companiesdrug-development
Full data — links, identifiers, deals & radar signals (jobs, patents, research, more)

External links

Websiteprotalix.com
LinkedInlinkedin.com/company/739969
X / Twittertwitter.com/protalix_bio
Facebookfacebook.com/ProtalixBio
Wikipediaen.wikipedia.org/wiki/Protalix_BioTherapeutics
Wikidatawikidata.org/wiki/Q7251166

Identifiers & details

Legal nameProtalix BioTherapeutics Inc.
Founded1993
Employees (exact)226
Market cap$79.2M
Status reasonPublic on AMEX on Dec, 2006;Public on TASE on Nov, 2010;Public on NYSE on Mar, 2011;
Wikidata QIDQ7251166

Acquisitions & public offerings

TypeDateExchangeTickerAmount
Reverse Merger2006-12NASDAQ
Public Offering2010-11TASEPLX
Public Offering2011-03NYSEPLX$22.0M
Public Offering2012-02NYSE AmericanPLX$25.4M
Public Offering2021-02NYSE AmericanPLX$40.0M

Radar intelligence

Web history (Wayback)

Domainprotalix.com

Wikidata

QIDQ7251166

Certificate / subdomain footprint

Subdomains8

Israeli Companies Registrar (רשם החברות / ICA)

Registrar # (ח.פ.)511903288
Statusפעילה
Corp typeישראלית חברה פרטית
Incorporated1993-12-27
Purposeלעסוק בסוגי עיסוק שפורטו בתקנון
Liabilityמוגבלת
In violation (unfiled)no
Last annual report2025
Active charges / liens1
Registry events3 — people (2), charge (1)
Registered addressסנונית 2 כרמיאל

Recent registry events

DateEvent
2025-11-24עדכון דירקטורים-הסרת דירקטור
2025-11-24עדכון דירקטורים-הוספת דירקטור
2025-12-17רישום שעבוד