Last updated 2026-07-26
- Raised $800k grant, Apr 2015
- Raised $1M grant, Jan 2015
- Raised $700k grant, Dec 1969
Total raised
$2.5M
Last: Grant 2017-01
Stage
Seed
Founded
2005
Headcount
2
HQ
Jerusalem, Israel
Sector
Health Tech & Life Sciences
About
Immune System Key (ISK) Ltd. is a privately held, clinical-stage biotechnology company focused on the discovery and development of innovative treatments for malignant and autoimmune diseases. The company's therapeutic assets are based on novel human secreted peptides discovered by its founders. ISK's lead compound, Nerofe™, is a peptide derivative being explored for various oncology indications, including Acute Myeloid Leukemia (AML), pancreatic cancer, and metastatic colorectal cancer, as well as Alzheimer's disease. ISK Ltd is a resident company of Johnson & Johnson Innovation – JLABS.
Funding history · 3 rounds · $2.5M total
2015-04
Grant
$800K
2015-01
Grant
$1.0M
1969-12
Grant
$700K
Headcount over time
From 2 (2018-09) to 2 (2025-10) · +0 (+0%) · 5 points · source: Finder history + radar grounding
Q&A
- What is Immune System Key's primary focus in drug development?
- Immune System Key (ISK) is focused on the discovery and development of treatments for malignant cancers and autoimmune diseases, specifically targeting acute myeloid leukemia (AML), pancreatic cancer, and triple-negative breast cancer.
- What is Immune System Key's lead compound and its key features?
- Immune System Key's lead compound is Nerofe, which aims to inhibit three biological processes supporting cancer progression. Phase-1 testing showed a strong anti-angiogenic effect and activation of anticancer immune response. Nerofe has been granted orphan status by the FDA for AML treatment.
- How many employees does Immune System Key currently have?
- Immune System Key has 1-10 employees.
- Who are the co-founders of Immune System Key?
- The co-founders of Immune System Key are Dr. Yoram Devary, who serves as Co-founder, Chairman & CTO, and Prof. Uziel Sandler, who is Co-founder, Vice-Chairman & CEO.
- What is the total amount of funding Immune System Key has raised?
- Immune System Key has raised a total of $3,700,000.
- When was Immune System Key founded?
- Immune System Key was founded in February 1992.
- Has Immune System Key received any grants from the Israel Innovation Authority?
- Yes, Immune System Key received grants from the Israel Innovation Authority in January 2016 and January 2017.
- What is the product stage of Immune System Key's developments?
- Immune System Key's developments are in the clinical trial stage.
Team · 2
Uziel Sandler
Founder · Co-Founder
Yoram Devary
Founder · Co-Founder
Sectors & technology
Primary sector
Health Tech & Life Sciences
Sub-sectors
Health Tech & Life SciencesPharma & Medical BiotechnologyBiomaterials & Tissue EngineeringDrugs Discovery & Development
Technologies
BiologicalsMolecules
Target customers
Healthcare & Life SciencesLife SciencesPharmaceuticalsBiotechnologyHealthcareProviders
Business model
B2BB2C
Highlights
1 Patents
Tags
cancerpharmaceuticalsoncologybiotechnologydrug-discoverypeptidestreatmentsautoimmune-diseaseshealthcare-providershospitals
Full data — links, identifiers, deals & radar signals (jobs, patents, research, more)
External links
| Website | immunesk.com |
|---|---|
| linkedin.com/company/2619379 |
Identifiers & details
| Legal name | Immune System Key Ltd. |
|---|---|
| Former names | ThymuFight |
| Founded | 2005 |
| Employees (exact) | 2 |
Radar intelligence
Patents
| EPO | 9 |
|---|
Web history (Wayback)
| Domain | immunesk.com |
|---|
Certificate / subdomain footprint
| Subdomains | 3 |
|---|
Israeli Companies Registrar (רשם החברות / ICA)
| Registrar # (ח.פ.) | 513754820 |
|---|---|
| Status | פעילה |
| Corp type | ישראלית חברה פרטית |
| Incorporated | 2005-11-24 |
| Purpose | לעסוק בכל עיסוק חוקי |
| Liability | מוגבלת |
| In violation (unfiled) | yes |
| Last annual report | 2023 |
| Active charges / liens | 0 |
| Registry events | 3 — people (1), violation (1), shares_capital (1) |
| Registered address | רוזנבלט 318 ירושלים |
Recent registry events
| Date | Event |
|---|---|
| 2025-10-30 | עדכון בעלי תפקידים |
| 2026-06-25 | עדכון הפרה |
| 2025-12-14 | העברת מניות |