Enlivex Therapeutics

Macrophage Reprogramming Cell Therapies for Life-threatening Diseases

Health Tech & Life Sciences
Active
Public Ness Ziona Founded 2005
Total raised
$286.9M
Last: PIPE 2025-11
Stage
Public
Founded
2005
Headcount
35
HQ
Ness Ziona
Sector
Health Tech & Life Sciences

About

Enlivex Therapeutics is a clinical-stage company focused on macrophage reprogramming. The company intends to develop and commercialize a drug pipeline for macrophage reprogramming in solid cancers, sepsis, COVID-19, and other indications. The company's most advanced product candidate, Allocetra, was developed for the reprogramming of diseased macrophages in patients with sepsis or COVID-19, and has demonstrated positive safety, tolerability, and efficacy in several clinical trials. In March 2019, the company announced the completion of its merger with Tel Aviv-headquartered Bioblast Pharma. Following the reverse merger, Enlivex became a subsidiary of Bioblast, which was renamed Enlivex Therapeutics.

Funding history · 4 rounds · $286.9M total

2025-11
PIPE $212.0M
2017-09
Series B $8.0M
2014-05
Debt Financing $7.0M
Date unknown
PIPE $15.0M

Company Intelligence Q&A

Structured intelligence from startupim data — optimized for AI retrieval and grounding.

What was a significant corporate development for Enlivex Therapeutics in March 2019?
In March 2019, Enlivex Therapeutics completed a merger with Tel Aviv-headquartered Bioblast Pharma. Following this reverse merger, Enlivex became a subsidiary of Bioblast, which was then renamed Enlivex Therapeutics.
When did Enlivex Therapeutics become a public company on NASDAQ?
Enlivex Therapeutics became public on NASDAQ in March 2019.
What was the total amount raised by Enlivex Therapeutics in funding rounds?
According to startupim data, Enlivex Therapeutics has raised a total of $286,900,000 USD in funding.
What was the most recent funding round for Enlivex Therapeutics, and when did it occur?
The most recent funding round for Enlivex Therapeutics was a PIPE round in November 2025, which raised $212,000,000 USD.
Which investors participated in Enlivex Therapeutics' Series B round in September 2017?
The Series B round in September 2017 included investors Hadasit Bio-Holdings and Korea Investment Partners.
What is Enlivex Therapeutics' most advanced product candidate and its primary indications?
Enlivex Therapeutics' most advanced product candidate is Allocetra, developed for reprogramming diseased macrophages in patients with sepsis or COVID-19.
What was the amount of the grant Enlivex Therapeutics received from the IIA in May 2021?
In May 2021, Enlivex Therapeutics received a grant of $1,100,000 USD from the IIA.
When did Enlivex Therapeutics announce positive interim data for Allocetra in patients with moderate to severe knee osteoarthritis?
In March 2025, Enlivex announced positive interim data for Allocetra, showing a statistically significant 47.0% durable and persistent pain reduction at six months in patients with moderate to severe knee osteoarthritis.
What regulatory authorization did Enlivex Therapeutics receive in December 2024?
In December 2024, Enlivex Therapeutics received Israeli regulatory authorization to commence a Phase I trial evaluating Allocetra in patients with TMJ osteoarthritis.
What was a key development regarding Allocetra's patent coverage in February 2024?
In February 2024, Enlivex announced the issuance of a new U.S. patent covering Allocetra cells and their manufacturing method.

Sectors & technology

Primary sector
Health Tech & Life Sciences
Sub-sectors
Health Tech & Life SciencesPharma & Medical BiotechnologyDrugs Discovery & Development
Technologies
BiologicalsCells
Target customers
Healthcare & Life SciencesLife SciencesPharmaceuticalsBiotechnologyHealthcareProvidersPatients
Business model
B2B

Highlights

1 Patents

Tags

cell-therapyinflammatory-diseasescrohn-s-diseasepharmaceuticalscancerimmunologyimmunotherapypharma-companieschronic-patientspatientsautoimmune-diseases